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This is exactly why GHRPs (Ipamorelin, MK-677, the ghrelin-receptor class), GnRH analogs, and broad melanocortin agonists like Melanotan II genuinely need cycling

Then there's tirzepatide that mimics both GLP-1 and GIP

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Cardiovascular and metabolic diseases including obesity remain important areas of unmet medical need, and we plan to continue applying our global capabilities to advance a pipeline of investigational treatments that have the potential to fill critical gaps in patient care, including continued development of our oral GIPR antagonist candidate and other earlier obesity programs, said Chris Boshoff, MD, PhD, Chief Scientific Officer and President, Research and Development at Pfizer